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X-WR-CALNAME:UCLA | Bioinformatics
X-ORIGINAL-URL:https://bioinformatics.ucla.edu
X-WR-CALDESC:Events for UCLA | Bioinformatics
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DTSTART:20160101T000000
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BEGIN:VEVENT
DTSTART;TZID=UTC:20170227T160000
DTEND;TZID=UTC:20170227T170000
DTSTAMP:20170207T004302Z
CREATED:20170207T004302Z
LAST-MODIFIED:20170207T004302Z
UID:2347-1488211200-1488214800@bioinformatics.ucla.edu
SUMMARY:Adam Siepel Seminar
DESCRIPTION:Abstract:  Transcriptional regulatory changes have been shown to contribute to phenotypic differences between species\, but many questions remain about how gene expression evolves. In this talk\, I will present the first comparative study of nascent transcription in primates. We used PRO-seq to map actively transcribing RNA polymerases in resting and activated CD4+ T-cells in multiple human\, chimpanzee\, and rhesus macaque individuals\, with rodents as outgroups. This approach allowed us to directly measure active transcription separately from post-transcriptional processes. We observed general conservation in coding and non-coding transcription\, punctuated by numerous differences between species\, particularly at distal enhancers and non-coding RNAs. Transcription factor binding sites are a primary determinant of transcriptional differences between species. We found evidence for stabilizing selection on gene expression levels and adaptive substitutions associated with lineage-specific transcription. Finally\, rates of evolutionary change are strongly correlated with long-range chromatin interactions. These observations clarify the role of primary transcription in regulatory evolution.
URL:https://bioinformatics.ucla.edu/event/adam-siepel-seminar/
LOCATION:Boyer Hall 159
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