Project start date: Winter 2013
Project title: Construction of a genomics-based body atlas of drugs using microarray and RNA-sequencing data
Project contact: Xia Yang (email@example.com)
Project description: Drug molecules’ genomic footprints can infer mechanisms of action. By measuring how a pharmacological agent affects the expression of genes of a cell or a tissue type, we can derive cell- or tissue-specific biological pathways involved in the therapeutic effects. This project aims to systematically analyze public microarray and RNA-sequencing data from different cells and tissues in mouse and human to identify genes and biological processes that correlate with the use of therapeutic drugs.
Required Experience: Good programming skills. Experience with R/Bioconductor and basic knowledge of microarrays and RNA sequencing technologies a plus.